HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 11530378, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (2R)-(-)-2-Methylpyrrolidine hydrochloride | HCID 11147704 | — |
| Reactant | Methanesulfonic acid 2-[2-(4-bromo-phenyl)-5-methyl-oxazol-4-yl]-ethyl ester | HCID 11451238 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 11530378 | HCID 11530378 | 103.4% |
Reaction Steps
Prepare using the method of Example 102 with 2-[2-(4-bromophenyl)-5-methyl-1,3-oxazol-4-yl]ethyl methanesulfonate (See Intermediate 13) (0.65 g, 1.80 mmole), anhydrous acetonitrile (6 mL), potassium carbonate (0.87 g, 6.32 mmol), potassium iodide (0.03 g, 0.18 mmol) and (2R)-2-methylpyrrolidine hydrochloride (salt) (See Intermediate 7) (0.25 g, 2.08 mmol) to give the title compound as a pale orange oil (0.65 g): MS (m/e) (79Br/81Br): 349, 351(M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666871B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-31bb789d1f0141f696fe70930290060f |
| Source note | uspto-grants-2010_02 |