4-(Chloromethyl)-2-methyl-1,3-thiazole--hydrogen chloride (1/1) → HCID 11654150, compound

HRID 1445862Notes

Reaction equation

HRID 1445862 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:22])=[C:11]([CH2:13][C:14]([N:16]3[CH2:20][CH2:19][CH2:18][C@H:17]3[CH3:21])=O)[N:12]=2)=[CH:4][CH:3]=1.Cl.Cl[CH2:25][C:26]1[N:27]=[C:28]([CH3:31])[S:29][CH:30]=1>>[CH3:22][C:10]1[O:9][C:8]([C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:25][C:26]3[N:27]=[C:28]([CH3:31])[S:29][CH:30]=3)=[CH:3][CH:4]=2)=[N:12][C:11]=1[CH2:13][CH2:14][N:16]1[CH2:20][CH2:19][CH2:18][C@H:17]1[CH3:21]

Participants

3

Reactant 2

HCID 27342034-(Chloromethyl)-2-methyl-1,3-thiazole--hydrogen chloride (1/1)HCID 135487319HCID 135487319, compound

Product 1

HCID 11654150HCID 11654150, compound

Procedure

The title compound is prepared in a manner substantially similar to Example 58 from 2-[2-(4-Hydroxy-phenyl)-5-methyl-oxazol-4-yl]-1-(2-(R)-methyl-pyrrolidin-1-yl)-ethanone (See Example 56) and 4-(chloromethyl)-2-methylthiazole hydrochloride. MS (m/e): 398.3 (M+1)

Sources & evidence

ORD record
ord-1edadf32e7004083b592f94697672c8e
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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