(2R)-(-)-2-Methylpyrrolidine hydrochloride → HCID 58951453, compound

HRID 1445866Notes

Reaction equation

HRID 1445866 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:16][CH:17]=[C:18]([CH2:20][CH2:21]O)[N:19]=2)=[CH:11][CH:10]=1.Cl.[CH3:24][C@@H:25]1[CH2:29][CH2:28][CH2:27][NH:26]1>>[CH3:24][C@@H:25]1[CH2:29][CH2:28][CH2:27][N:26]1[CH2:21][CH2:20][C:18]1[N:19]=[C:15]([C:12]2[CH:11]=[CH:10][C:9]([O:8][CH2:7][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)=[CH:14][CH:13]=2)[O:16][CH:17]=1

Participants

3

Reactant 2

HCID 11147704(2R)-(-)-2-Methylpyrrolidine hydrochlorideHCID 58951471HCID 58951471, compound2×

Product 1

HCID 58951453HCID 58951453, compound

Procedure

The title compound is prepared in a manner substantially similar to Example 53 from 2-{2-[4-(Pyridin-2-ylmethoxy)-phenyl]-oxazol-4-yl}-ethanol (See Intermediate 66) and (R)-2-methylpyrrolidine hydrochloride [CAS 41720-98-3]. MS (m/e): 364.2 (M+1)

Sources & evidence

ORD record
ord-b4fb1adb6fd945d9ba53eaad44e5c176
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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