(2R)-(-)-2-Methylpyrrolidine hydrochloride → HCID 11717648, compound

HRID 1445867Notes

Reaction equation

HRID 1445867 reaction equation
[S:1]1[CH:5]=[C:4]([CH2:6][O:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]3[O:15][CH:16]=[C:17]([CH2:19][CH2:20]O)[N:18]=3)=[CH:10][CH:9]=2)[N:3]=[CH:2]1.Cl.[CH3:23][C@@H:24]1[CH2:28][CH2:27][CH2:26][NH:25]1>>[CH3:23][C@@H:24]1[CH2:28][CH2:27][CH2:26][N:25]1[CH2:20][CH2:19][C:17]1[N:18]=[C:14]([C:11]2[CH:10]=[CH:9][C:8]([O:7][CH2:6][C:4]3[N:3]=[CH:2][S:1][CH:5]=3)=[CH:13][CH:12]=2)[O:15][CH:16]=1

Participants

3

Reactant 2

HCID 11147704(2R)-(-)-2-Methylpyrrolidine hydrochlorideHCID 58951462HCID 58951462, compound2×

Product 1

HCID 11717648HCID 11717648, compound

Procedure

The title compound is prepared in a manner substantially similar to Example 53 from 2-{2-[4-(Thiazol-4-ylmethoxy)-phenyl]-oxazol-4-yl}-ethanol (See Intermediate 68) and (R)-2-methylpyrrolidine hydrochloride [CAS 41720-98-3]. MS (m/e): 370.2 (M+1)

Sources & evidence

ORD record
ord-423daff2734d49cdb8636e407c78f4de
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

Loading…