(2R)-(-)-2-Methylpyrrolidine hydrochloride → HCID 11495239, compound

HRID 1445868Notes

Reaction equation

HRID 1445868 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17]3[O:18][CH:19]=[C:20]([CH2:22][CH2:23]O)[N:21]=3)=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].Cl.[CH3:26][C@@H:27]1[CH2:31][CH2:30][CH2:29][NH:28]1>>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[CH:13][C:14]([C:17]3[O:18][CH:19]=[C:20]([CH2:22][CH2:23][N:28]4[CH2:29][CH2:30][CH2:31][C@H:27]4[CH3:26])[N:21]=3)=[CH:15][CH:16]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 11147704(2R)-(-)-2-Methylpyrrolidine hydrochlorideHCID 58951406HCID 58951406, compound2×

Product 1

HCID 11495239HCID 11495239, compound

Procedure

The title compound is prepared in a manner substantially similar to Example 53 from 2-[2-(4′-Methanesulfonyl-biphenyl-4-yl)-oxazol-4-yl]-ethanol (See Intermediate 71) and (R)-2-methylpyrrolidine hydrochloride [CAS 41720-98-3]. MS (m/e): 411.2 (M+1)

Sources & evidence

ORD record
ord-7965438c31cb4e8fb21d6a4e586f71f5
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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