2-Acetylphenylboronic acid → HCID 11646766, compound

HRID 1445870Notes

Reaction equation

HRID 1445870 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1B(O)O)(=[O:3])[CH3:2].Br[C:14]1[CH:19]=[CH:18][C:17]([C:20]2[O:21][C:22]([CH3:33])=[C:23]([CH2:25][CH2:26][N:27]3[CH2:31][CH2:30][CH2:29][C@H:28]3[CH3:32])[N:24]=2)=[CH:16][CH:15]=1>>[CH3:33][C:22]1[O:21][C:20]([C:17]2[CH:18]=[CH:19][C:14]([C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[C:1](=[O:3])[CH3:2])=[CH:15][CH:16]=2)=[N:24][C:23]=1[CH2:25][CH2:26][N:27]1[CH2:31][CH2:30][CH2:29][C@H:28]1[CH3:32]

Participants

3

Reactant 2

HCID 27343092-Acetylphenylboronic acidHCID 11530378HCID 11530378, compound

Product 1

HCID 11646766HCID 11646766, compound

Procedure

The title compound is prepared in a manner substantially analogous to example 133 starting from 2-acetylphenyl boronic acid (235 mg, 1.43 mmol) and 2-(4-Bromo-phenyl)-5-methyl-4-[2-((R)-2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole (100 mg, 0.287 mmol) to give 94 mg (85%). MS (m/e) 389.2 (M+1)

Workup

  1. customto give 94 mg (85%)

Sources & evidence

ORD record
ord-10fa1bf027e2404f8ec172ba26e7b772
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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