2-Cyanophenylboronic acid → HCID 11646417, compound

HRID 1445872Notes

Reaction equation

HRID 1445872 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1B(O)O)#[N:2].Br[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[O:20][C:21]([CH3:32])=[C:22]([CH2:24][CH2:25][N:26]3[CH2:30][CH2:29][CH2:28][C@H:27]3[CH3:31])[N:23]=2)=[CH:15][CH:14]=1>>[CH3:32][C:21]1[O:20][C:19]([C:16]2[CH:17]=[CH:18][C:13]([C:4]3[C:3]([C:1]#[N:2])=[CH:8][CH:7]=[CH:6][CH:5]=3)=[CH:14][CH:15]=2)=[N:23][C:22]=1[CH2:24][CH2:25][N:26]1[CH2:30][CH2:29][CH2:28][C@H:27]1[CH3:31]

Participants

3

Reactant 2

HCID 27346102-Cyanophenylboronic acidHCID 11530378HCID 11530378, compound

Product 1

HCID 11646417HCID 11646417, compound

Procedure

The title compound is prepared in a manner substantially analogous to example 133 starting from 2-Cyanobenzene boronic acid (211 mg, 1.43 mmol) and 2-(4-Bromo-phenyl)-5-methyl-4-[2-((R)-2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole (100 mg, 0.287 mmol) to give 70 mg (66%). MS (m/e) 372.2 (M+1)

Workup

  1. customto give 70 mg (66%)

Sources & evidence

ORD record
ord-5d33c0e7d4e9469b8d73f922934b6a5e
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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