3-Fluorophenylboronic acid → HCID 11595717, compound

HRID 1445874Notes

Reaction equation

HRID 1445874 reaction equation
[F:1][C:2]1[CH:3]=[C:4](B(O)O)[CH:5]=[CH:6][CH:7]=1.Br[C:12]1[CH:17]=[CH:16][C:15]([C:18]2[O:19][C:20]([CH3:31])=[C:21]([CH2:23][CH2:24][N:25]3[CH2:29][CH2:28][CH2:27][C@H:26]3[CH3:30])[N:22]=2)=[CH:14][CH:13]=1>>[F:1][C:2]1[CH:3]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[O:19][C:20]([CH3:31])=[C:21]([CH2:23][CH2:24][N:25]4[CH2:29][CH2:28][CH2:27][C@H:26]4[CH3:30])[N:22]=3)=[CH:14][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 27339863-Fluorophenylboronic acidHCID 11530378HCID 11530378, compound

Product 1

HCID 11595717HCID 11595717, compound

Procedure

The title compound is prepared in a manner substantially analogous to example 133 starting from 3-fluorobenzene boronic acid (201 mg, 1.43 mmol) and 2-(4-Bromo-phenyl)-5-methyl-4-[2-((R)-2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole (100 mg, 0.287 mmol) to give 70 mg (67%). MS (m/e) 365.2 (M+1)

Workup

  1. customto give 70 mg (67%)

Sources & evidence

ORD record
ord-bda4d0851ad84c4aba92953b55c5dbf6
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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