2-Fluorophenylboronic acid → HCID 11639174, compound

HRID 1445875Notes

Reaction equation

HRID 1445875 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1B(O)O.Br[C:12]1[CH:17]=[CH:16][C:15]([C:18]2[O:19][C:20]([CH3:31])=[C:21]([CH2:23][CH2:24][N:25]3[CH2:29][CH2:28][CH2:27][C@H:26]3[CH3:30])[N:22]=2)=[CH:14][CH:13]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]1[CH:17]=[CH:16][C:15]([C:18]2[O:19][C:20]([CH3:31])=[C:21]([CH2:23][CH2:24][N:25]3[CH2:29][CH2:28][CH2:27][C@H:26]3[CH3:30])[N:22]=2)=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 27343542-Fluorophenylboronic acidHCID 11530378HCID 11530378, compound

Product 1

HCID 11639174HCID 11639174, compound

Procedure

The title compound is prepared in a manner substantially analogous to example 133 starting from 2-fluorobenzene boronic acid (201 mg, 1.43 mmol) and 2-(4-Bromo-phenyl)-5-methyl-4-[2-((R)-2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole (100 mg, 0.287 mmol) to give 61 mg (59%). MS (m/e) 365.2 (M+1)

Workup

  1. customto give 61 mg (59%)

Sources & evidence

ORD record
ord-f24f614c1da04c738544bb3ffbff2630
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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