2-Methoxyphenylboronic acid → HCID 58951400, compound

HRID 1445878Notes

Reaction equation

HRID 1445878 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1B(O)O.Br[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[O:20][C:21]([CH3:32])=[C:22]([CH2:24][CH2:25][N:26]3[CH2:30][CH2:29][CH2:28][C@H:27]3[CH3:31])[N:23]=2)=[CH:15][CH:14]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[O:20][C:21]([CH3:32])=[C:22]([CH2:24][CH2:25][N:26]3[CH2:30][CH2:29][CH2:28][C@H:27]3[CH3:31])[N:23]=2)=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 27339582-Methoxyphenylboronic acidHCID 11530378HCID 11530378, compound

Product 1

HCID 58951400HCID 58951400, compound

Procedure

The title compound is prepared in a manner substantially analogous to example 133 starting from 2-methoxybenzene boronic acid (218 mg, 1.43 mmol) and 2-(4-Bromo-phenyl)-5-methyl-4-[2-((R)-2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole (100 mg, 0.287 mmol) to give 67 mg (62%). MS (m/e) 377.2 (M+1)

Workup

  1. customto give 67 mg (62%)

Sources & evidence

ORD record
ord-198709f6dcc14b6fa1bda9974b9064e8
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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