3-Cyanophenylboronic acid → HCID 58951482, compound

HRID 1445879Notes

Reaction equation

HRID 1445879 reaction equation
[C:1]([C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][CH:8]=1)#[N:2].Br[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[O:20][C:21]([CH3:31])=[C:22]([CH2:24][CH2:25][N:26]3[CH2:30][CH2:29][CH2:28][CH2:27]3)[N:23]=2)=[CH:15][CH:14]=1>>[CH3:31][C:21]1[O:20][C:19]([C:16]2[CH:17]=[CH:18][C:13]([C:7]3[CH:6]=[CH:5][CH:4]=[C:3]([C:1]#[N:2])[CH:8]=3)=[CH:14][CH:15]=2)=[N:23][C:22]=1[CH2:24][CH2:25][N:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 27343253-Cyanophenylboronic acidHCID 116815462-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

Product 1

HCID 58951482HCID 58951482, compound

Procedure

The title compound is prepared in a manner substantially analogous to example 133 starting from 3-cyanobenzene boronic acid (219 mg, 1.49 mmol) and 2-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole (100 mg, 0.30 mmol) to give 21 mg (20%). MS (m/e) 358.2 (M+1)

Workup

  1. customto give 21 mg (20%)

Sources & evidence

ORD record
ord-70050c2b45784131953564a4846ad5e1
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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