Tolylboronic acid → HCID 58951404, compound

HRID 1445881Notes

Reaction equation

HRID 1445881 reaction equation
B(O)(O)[C:2]1[CH:3]=[CH:4][C:5]([CH3:8])=[CH:6][CH:7]=1.Br[C:12]1[CH:17]=[CH:16][C:15]([C:18]2[O:19][C:20]([CH3:31])=[C:21]([CH2:23][CH2:24][N:25]3[CH2:29][CH2:28][CH2:27][C@H:26]3[CH3:30])[N:22]=2)=[CH:14][CH:13]=1>>[CH3:31][C:20]1[O:19][C:18]([C:15]2[CH:16]=[CH:17][C:12]([C:2]3[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][CH:3]=3)=[CH:13][CH:14]=2)=[N:22][C:21]=1[CH2:23][CH2:24][N:25]1[CH2:29][CH2:28][CH2:27][C@H:26]1[CH3:30]

Participants

3

Reactant 2

HCID 79799Tolylboronic acidHCID 11530378HCID 11530378, compound

Product 1

HCID 58951404HCID 58951404, compound

Procedure

The title compound is prepared in a manner substantially analogous to example 133 starting from tolyl boronic acid (195 mg, 1.43 mmol) and 2-(4-Bromo-phenyl)-5-methyl-4-[2-((R)-2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole (100 mg, 0.287 mmol) to give 33 mg (32%). MS (m/e) 361.3 (M+1)

Workup

  1. customto give 33 mg (32%)

Sources & evidence

ORD record
ord-51bf405cf0664574ace90a10c4e36a0d
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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