(Pyrimidin-5-yl)boronic acid → HCID 58951472, compound

HRID 1445883Notes

Reaction equation

HRID 1445883 reaction equation
[N:1]1[CH:6]=[C:5](B(O)O)[CH:4]=[N:3][CH:2]=1.Br[C:11]1[CH:16]=[CH:15][C:14]([C:17]2[O:18][C:19]([CH3:30])=[C:20]([CH2:22][CH2:23][N:24]3[CH2:28][CH2:27][CH2:26][C@H:25]3[CH3:29])[N:21]=2)=[CH:13][CH:12]=1>>[CH3:30][C:19]1[O:18][C:17]([C:14]2[CH:15]=[CH:16][C:11]([C:5]3[CH:6]=[N:1][CH:2]=[N:3][CH:4]=3)=[CH:12][CH:13]=2)=[N:21][C:20]=1[CH2:22][CH2:23][N:24]1[CH2:28][CH2:27][CH2:26][C@H:25]1[CH3:29]

Participants

3

Reactant 2

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 11530378HCID 11530378, compound

Product 1

HCID 58951472HCID 58951472, compound

Procedure

The title compound is prepared in a manner substantially analogous to example 133 starting from 5-pyrimidine boronic acid (178 mg, 1.43 mmol) and 2-(4-Bromo-phenyl)-5-methyl-4-[2-((R)-2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole (100 mg, 0.287 mmol) to give 40 mg (40%). MS (m/e) 349.3 (M+1)

Workup

  1. customto give 40 mg (40%)

Sources & evidence

ORD record
ord-1fb52c140f5943c48ad3ddd7d651f0fd
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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