(4-(Pyrrolidine-1-carbonyl)phenyl)boronic acid → HCID 58951435, compound

HRID 1445884Notes

Reaction equation

HRID 1445884 reaction equation
[N:1]1([C:6]([C:8]2[CH:13]=[CH:12][C:11](B(O)O)=[CH:10][CH:9]=2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.Br[C:18]1[CH:23]=[CH:22][C:21]([C:24]2[O:25][C:26]([CH3:37])=[C:27]([CH2:29][CH2:30][N:31]3[CH2:35][CH2:34][CH2:33][C@H:32]3[CH3:36])[N:28]=2)=[CH:20][CH:19]=1>>[CH3:37][C:26]1[O:25][C:24]([C:21]2[CH:22]=[CH:23][C:18]([C:11]3[CH:12]=[CH:13][C:8]([C:6]([N:1]4[CH2:5][CH2:4][CH2:3][CH2:2]4)=[O:7])=[CH:9][CH:10]=3)=[CH:19][CH:20]=2)=[N:28][C:27]=1[CH2:29][CH2:30][N:31]1[CH2:35][CH2:34][CH2:33][C@H:32]1[CH3:36]

Participants

3

Reactant 2

HCID 2773571(4-(Pyrrolidine-1-carbonyl)phenyl)boronic acidHCID 11530378HCID 11530378, compound

Product 1

HCID 58951435HCID 58951435, compound

Procedure

The title compound is prepared in a manner substantially analogous to example 133 starting from 4-pyrrolidine-1-carbonyl phenyl boronic acid (314 mg, 1.43 mmol) and 2-(4-Bromo-phenyl)-5-methyl-4-[2-((R)-2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole (100 mg, 0.287 mmol) to give 55 mg (43%). MS (m/e) 444.4 (M+1)

Workup

  1. customto give 55 mg (43%)

Sources & evidence

ORD record
ord-1fc1c4435e3b44d0bd94af34e731cc8b
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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