4-Aminocarbonylphenylboronic acid → HCID 58951408, compound

HRID 1445885Notes

Reaction equation

HRID 1445885 reaction equation
[NH2:1][C:2]([C:4]1[CH:9]=[CH:8][C:7](B(O)O)=[CH:6][CH:5]=1)=[O:3].Br[C:14]1[CH:19]=[CH:18][C:17]([C:20]2[O:21][C:22]([CH3:33])=[C:23]([CH2:25][CH2:26][N:27]3[CH2:31][CH2:30][CH2:29][C@H:28]3[CH3:32])[N:24]=2)=[CH:16][CH:15]=1>>[CH3:33][C:22]1[O:21][C:20]([C:17]2[CH:18]=[CH:19][C:14]([C:7]3[CH:8]=[CH:9][C:4]([C:2]([NH2:1])=[O:3])=[CH:5][CH:6]=3)=[CH:15][CH:16]=2)=[N:24][C:23]=1[CH2:25][CH2:26][N:27]1[CH2:31][CH2:30][CH2:29][C@H:28]1[CH3:32]

Participants

3

Reactant 2

HCID 27378114-Aminocarbonylphenylboronic acidHCID 11530378HCID 11530378, compound

Product 1

HCID 58951408HCID 58951408, compound

Procedure

The title compound is prepared in a manner substantially analogous to example 133 starting from 4-aminocarbonyl phenyl boronic acid (236 mg, 1.43 mmol) and 2-(4-Bromo-phenyl)-5-methyl-4-[2-((R)-2-methyl-pyrrolidin-1-yl)-ethyl]-oxazole (100 mg, 0.287 mmol) to give 17 mg (15%). MS (m/e) 390.3 (M+1)

Workup

  1. customto give 17 mg (15%)

Sources & evidence

ORD record
ord-f2d0377902e24b43a0e9a7da12851141
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

Loading…