(1-Benzyl-2-methyl-1H-indol-4-yloxy)-acetic acid ethyl ester → (1-Benzyl-2-methyl-1H-indol-4-yloxy)-acetic acid

Participants

Reaction Steps

To a solution of (1-benzyl-2-methyl-1H-indol-4-yloxy)-acetic acid ethyl ester (4) (0.80 g, 2.48 mmole) in THF:H2O (4:1, 10 mL), lithium hydroxide monohydrate was added (0.118 g, 4.96 mmole). The mixture was stirred at room temperature for 1 h. THF was evaporated and then crushed ice was added to the aqueous mixture; the resulting solid was collected by filtration to afford intermediate (5) as a solid. Yield: 0.67 g, 92% 1H NMR: 05-038-055

Provenance & Evidence