Water → 3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester 4-thiocarbamoyl benzoate

HRID 1445952Notes

Reaction equation

HRID 1445952 reaction equation
[C:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)(=[S:3])[NH2:2].[CH3:13][CH2:14][C:15]([N:38]([CH3:40])[CH3:39])([C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)[CH2:16][O:17][C:18]([C:20]1[CH:21]=[C:22]([O:30][CH3:31])[C:23]([O:28][CH3:29])=[C:24]([O:26][CH3:27])[CH:25]=1)=[O:19].O>C(O)C>[C:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)(=[S:3])[NH2:2].[CH3:40][N:38]([CH3:39])[C:15]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)([CH2:14][CH3:13])[CH2:16][O:17][C:18](=[O:19])[C:20]1[CH:25]=[C:24]([O:26][CH3:27])[C:23]([O:28][CH3:29])=[C:22]([O:30][CH3:31])[CH:21]=1

Participants

5

Reactant 3

HCID 962WaterHCID 5573TrimebutineHCID 167725014-Carbamothioylbenzoic acid

Product 1

HCID 866165533,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester 4-thiocarbamoyl benzoate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of 4-(thiocarbamoyl) benzoic acid (0.1 mol) and trimebutine (0.1 mol), water (200 mL) and ethyl alcohol (20 mL) have been added and the resulting suspension has been stirred at room temperature until clear. Then the solution has been frozen and lyophilized furnishing the desired salt (quantitative yield).

Workup

  1. additionhave been added
  2. temperatureThen the solution has been frozen

Sources & evidence

ORD record
ord-c7e76be668bf4ee98a125baaef6d4816
Source dataset
uspto-grants-2010_02
Patent number
US07666907B2

Reaction notes

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