HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Ethyl N-phenylglycinate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | N-Phenylglycine | HCID 66025 | — |
| Product | Ethyl N-phenylglycinate hydrochloride | HCID 12241367 | 98% |
Reaction Steps
22 mL of SOCl2 were added dropwise to a solution of 30 g of phenylglycin 1 (198.5 mmol) in 200 mL of anhydrous ethanol. A gentle reflux occurred spontaneously and it was maintained for 3 h. The reaction was allowed to cool to room temperature and was stirred overnight. The solvent was removed under vacuum to afford 41.8 g of 2 as a white powder (98% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666907B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-0d7aa126c51e4c17a65bde4d90e4e715 |
| Source note | uspto-grants-2010_02 |