huagongshe.com
HRID1445978

反应详情

EQUATION

反应方程式

HRID 1445978 的结构方程式

REACTANTS

反应物

2
结构：Nc1ccccc1
HCID6115

Aniline

C6H7N

结构：COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C(C3=O)[C@@H]2CC[C@H](O)[C@@]2(C)C[C@H]1OC(C)=O
HCID9867340

未命名化合物

PRODUCTS

生成物

1
结构：COC[C@H]1OC(=O)/C(=C/Nc2ccccc2)C2=C(O)C(=O)C3=C([C@H](OC(C)=O)C[C@]4(C)[C@@H](O)CC[C@@H]34)[C@]21C
HCID68541839

未命名化合物

收率 42.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of 50 mg (0.116 mmol) 17-hydroxywortmannin in 1 mL CH2Cl2 is added 26.2 mL (0.287 mmol) aniline. The reaction mixture is stirred at room temperature for 1 week and then concentrated in vacuo. The residue is dissolved in EtOAc and triturated with hexane to give a yellow powder. The yellow powder is purified by silica gel chromatography, (hexane/EtOAc) to give an oil. The oil is triturated with hexane to give 26 mg (42.8%) product as an orange powder. HRMS (ESI) m/z calcd for C29H33NO8 523.22074, found: 524.22692 (M+H)+1.

WORKUP

后处理

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue is dissolved in EtOAc
  3. customtriturated with hexane
  4. customto give a yellow powder
  5. customThe yellow powder is purified by silica gel chromatography, (hexane/EtOAc)
  6. customto give an oil
  7. customThe oil is triturated with hexane