1,3-Propanediamine, N1,N1,N3-trimethyl- → (1E,4S,4aR,5R,6aS,7S)-1-{[[3-(dimethylamino)propyl](methyl)amino]methylene}-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate

Beteiligte Stoffe

Reaktionsschritte

To a solution of 50 mg (0.12 mmol) 17-hydroxywortmannin in 0.5 mL CH2Cl2 is added 27.9 mg (0.24 mmol) N,N,N′-trimethyl-1,3-propanediamine. The reaction mixture is stirred at room temperature overnight. CH2Cl2 is removed in vacuo. The residue is triturated with Et2O to give 24 mg (36.6%) product as an orange powder. MS (ESI) m/z 547.3 (M+1).

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