HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyclohexylpiperazine → (1E,4S,4aR,5R,6aS,7S)-1-[(4-cyclohexylpiperazin-1-yl)methylene]-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyclohexylpiperazine | HCID 87298 | — |
| Reactant | 17beta-Hydroxy wortmannin | HCID 9867340 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (1E,4S,4aR,5R,6aS,7S)-1-[(4-cyclohexylpiperazin-1-yl)methylene]-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate | HCID 11642863 | 22.3% |
Reaction Steps
To a solution of 50 mg (0.12 mmol) 17-hydroxywortmannin in 0.5 mL CH2Cl2 is added 40.4 mg (0.24 mmol) 1-cyclohexylpiperazine. The reaction mixture is stirred at room temperature overnight. CH2Cl2 is removed in vacuo. The residue is triturated with Et2O to give 16 mg (22%) product as an orange powder. MS (ESI) m/z 599.35 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666901B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-83dbed54d3934739b4fa6d391779a4a3 |
| Source note | uspto-grants-2010_02 |