N'-(3-(Dimethylamino)propyl)-N,N-dimethyl-1,3-propanediamine → Acetic acid 4-{[bis-(3-dimethylamino-propyl)-amino]-methylene}-6,17-dihydroxy-1-methoxymethyl-10,13-dimethyl-3,7-dioxo-1,3,4,7,10,11,12,13,14,15,16,17-dodecahydro-2-oxa-cyclopenta[a]phenanthren-11-yl ester

Participants

Reaction Steps

To a solution of 100 mg (0.23 mmol) 17-hydroxywortmannin in 2 mL CH2Cl2 is added 3,3′-iminobis(N,N-dimethylpropylamine) (104 μL, 0.46 mmol). The reaction mixture is stirred at room temperature for 12 hours and then concentrated in vacuo. The residue is dissolved in EtOAc and precipitated with hexane. The precipitate is washed two times with hexane to give the product as a yellow solid. MS (ESI) m/z 619 (M+H).

Provenance & Evidence