HCID 68544866, compound → HCID 44242137, compound

HRID 1446056Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([N:29]2[CH2:33][CH:32]([CH2:34][NH:35][C:36](=[O:38])[CH3:37])[O:31][C:30]2=[O:39])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][O:16][CH:17]2[CH2:22][O:21][C:20]3=[N:23][C:24]([N+:26]([O-:28])=[O:27])=[CH:25][N:19]3[CH2:18]2)=[CH:11][CH:10]=1.ClCC1C=CC(OC2C=CC(N3CC(CNC(=O)C)OC3=O)=CC=2F)=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([N:29]2[CH2:33][C@H:32]([CH2:34][NH:35][C:36](=[O:38])[CH3:37])[O:31][C:30]2=[O:39])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][O:16][C@@H:17]2[CH2:22][O:21][C:20]3=[N:23][C:24]([N+:26]([O-:28])=[O:27])=[CH:25][N:19]3[CH2:18]2)=[CH:13][CH:14]=1

Participants

Reactant 2

HCID 68544866HCID 68544866, compound

HCID 68549128HCID 68549128, compound

Product 1

HCID 44242137HCID 44242137, compound

Procedure

N-(3-{3-Fluoro-4-[4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-phenoxy]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide. The title compound was prepared by following the same procedure as described in the preparation of Example 4, except N-{3-[4-(4-chloromethyl-phenoxy)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide was used in place of methanesulfonic acid 6-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxy}-pyridin-3-ylmethyl ester. ESI MS m/z 542.4 (M+H+).

Sources & evidence

ORD record: ord-608ede0a22d240cbba6aceb4e0eef9d5
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07666864B2

Reaction notes

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