HCID 68542202, compound → HCID 44242204, compound

Participants

Reaction Steps

N-(3-{3-Fluoro-4-[2-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxy)-pyridin-4-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide. The title compound was prepared by following the same procedure as described in the preparation of Example 7, except 6-(4-bromo-pyridin-2-yloxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine was used in place of 6-(5-bromo-pyridin-2-yloxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine. ESI MS m/z 513.3 (M+H+); 1H NMR (400 MHz, CDCl3) δ 8.17 (d, J=5.2 Hz, 1H), 7.57 (dd, J=13.2, 2.0 Hz, 1H), 7.46 (d, J=5.2 Hz, 1H), 7.43 (d, J=8.4 Hz, 1H), 7.29 (dd, J=9.2, 2.8 Hz, 1H), 7.17 (m, 1H), 6.94 (s, 1H), 6.07 (t, J=5.2 Hz, 1H), 5.78-5.79 (m, 1H), 4.85-4.82 (m, 2H), 4.55 (d, J=12.4 Hz, 1H), 4.40 (d, J=2.4 Hz, 2H), 3.82 (dd, J=8.8, 6.4 Hz, 1H), 3.72-3.63 (m, 2H), 2.03 (s, 3H).

Provenance & Evidence