HCID 44242274, compound → HCID 44242275, compound

HRID 1446058Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([N:29]2[CH2:33][C@H:32]([CH2:34][NH:35][C:36](=[O:38])[CH3:37])[O:31][C:30]2=[O:39])[CH:5]=[CH:6][C:7]=1[C:8]1[C:9](OC)=[N:10][C:11]([O:14][C@@H:15]2[CH2:20][O:19][C:18]3=[N:21][C:22]([N+:24]([O-:26])=[O:25])=[CH:23][N:17]3[CH2:16]2)=[N:12][CH:13]=1.BrC1[C:42](N(C)C)=[N:43][C:44](O[C@@H]2COC3=NC([N+]([O-])=O)=CN3C2)=NC=1>>[CH3:42][N:43]([CH3:44])[C:9]1[C:8]([C:7]2[CH:6]=[CH:5][C:4]([N:29]3[CH2:33][C@H:32]([CH2:34][NH:35][C:36](=[O:38])[CH3:37])[O:31][C:30]3=[O:39])=[CH:3][C:2]=2[F:1])=[CH:13][N:12]=[C:11]([O:14][C@@H:15]2[CH2:20][O:19][C:18]3=[N:21][C:22]([N+:24]([O-:26])=[O:25])=[CH:23][N:17]3[CH2:16]2)[N:10]=1

Participants

Reactant 2

HCID 44242274HCID 44242274, compound

HCID 68545435HCID 68545435, compound

Product 1

HCID 44242275HCID 44242275, compound

Procedure

(S,S)—N-(3-{3-Fluoro-4-[4-methoxy-2-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxy)-pyrimidin-5-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide. The title compound was prepared by following the same procedure as described in the preparation of Example 7, except [5-bromo-2-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6(S)-yloxy)-pyrimidin-4-yl]-dimethyl-amine was used in place of 6-(5-bromo-pyridin-2-yloxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine. ESI MS m/z 557.4 (M+H+).

Sources & evidence

ORD record: ord-7a37941408bd43c2b77fb6171a2145ee
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07666864B2

Reaction notes

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