HCID 44242274, compound → HCID 44242276, compound

HRID 1446059Notes

Reaction equation

HRID 1446059 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:29]2[CH2:33][C@H:32]([CH2:34][NH:35][C:36](=[O:38])[CH3:37])[O:31][C:30]2=[O:39])[CH:5]=[CH:6][C:7]=1[C:8]1C(OC)=N[C:11]([O:14][C@@H:15]2[CH2:20][O:19][C:18]3=[N:21][C:22]([N+:24]([O-:26])=[O:25])=[CH:23][N:17]3[CH2:16]2)=[N:12][CH:13]=1.[CH3:40][O:41][C:42](=[O:63])[C:43]1C=C(Br)C=N[C:44]=1O[C@@H]1COC2=NC([N+]([O-])=O)=CN2C1>>[CH3:40][O:41][C:42](=[O:63])[C:43]1[CH:44]=[C:8]([C:7]2[CH:6]=[CH:5][C:4]([N:29]3[CH2:33][C@H:32]([CH2:34][NH:35][C:36](=[O:38])[CH3:37])[O:31][C:30]3=[O:39])=[CH:3][C:2]=2[F:1])[CH:13]=[N:12][C:11]=1[O:14][C@@H:15]1[CH2:20][O:19][C:18]2=[N:21][C:22]([N+:24]([O-:26])=[O:25])=[CH:23][N:17]2[CH2:16]1

Participants

3

Reactant 2

HCID 44242274HCID 44242274, compoundHCID 68542428HCID 68542428, compound

Product 1

HCID 44242276HCID 44242276, compound

Procedure

(S,S)—N-(3-{3-Fluoro-4-[4-methoxy-2-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxy)-pyrimidin-5-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide. The title compound was prepared by following the same procedure as described in the preparation of Example 7, except 5-bromo-2-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6(S)-yloxy)-nicotinic acid methyl ester was used in place of 6(S)-(5-bromo-pyridin-2-yloxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine. ESI MS m/z 571.5 (M+H+).

Sources & evidence

ORD record
ord-c0a5785d9470407d98662bddb0e4b9bb
Source dataset
uspto-grants-2010_02
Patent number
US07666864B2

Reaction notes

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