HCID 44242340, compound → HCID 44242403, compound

Participants

Reaction Steps

(S,S)—N-(3-{3-Fluoro-4-[2-methyl-6-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxy)-pyridin-3-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide. The title compound was prepared by following the same procedure as described in the preparation of Example 7, except 6(S)-(5-bromo-4-trifluoromethyl-pyrimidin-2-yloxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine was used in place of 6(S)-(5-bromo-pyridin-2-yloxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine. ESI MS m/z 582.5 (M+H+); 1H NMR (400 MHz, CDCl3) δ 8.65 (s, 1H), 7.63 (d, J=11.6 Hz, 1H), 7.48 (s, 1H), 7.32-7.25 (m, 2H), 6.02 (t, J=6.2 Hz, 1H), 5.75 (s, 1H), 4.94 (d, J=12.0 Hz, 1H), 4.83-4.82 (m, 1H), 4.60 (d, J=12.4 Hz, 1H), 4.49 (brs, 2H), 4.10 (t, J=9.8 Hz, 1H), 3.84 (t, J=7.8 Hz, 1H), 3.72-3.62 (m, 2H), 2.04 (s, 3H).

Provenance & Evidence