HCID 131727896, compound → HCID 68548526, compound

Participants

Reaction Steps

5-(tert-Butyl-dimethyl-silanyloxymethyl)-3-[2-fluoro-4′-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-biphenyl-4-yl]-oxazolidin-2-one. The title compound was prepared by following the same procedure as described in the preparation of Example 26, except 3-(4-bromo-3-fluoro-phenyl)-5(S)-(tert-butyl-dimethyl-silanyloxymethyl)-oxazolidin-2-one was used in place of N-[3-(3,5-difluoro-4-iodo-phenyl)-2-oxo-oxazolidin-5(R)-ylmethyl]-acetamide. ESI MS m/z 599.6 (M+H+); 1H NMR (400 MHz, DMSO) δ 8.00 (s, 1H), 7.56 (dd, J=13.6, 2.4 Hz, 1H), 7.52-7.47 (m, 3H), 7.40-7.35 (m, 3H), 5.71 (s, 2H), 4.77-4.74 (m, 1H), 4.67-4.62 (m, 3H), 4.43 (d, J=11.6 Hz, 1H), 4.24-4.20 (m, 2H), 4.11 (t, J=9.2 Hz, 1H), 3.84 (dd, J=11.6, 2.4 Hz, 1H), 3.79 (dd, J=9.2, 5.2 Hz, 1H), 3.71 (dd, J=11.6, 2.8 Hz, 1H), 0.74 (s, 9H), 0.002 (s, 3H), 0.000 (s, 3H).

Provenance & Evidence