Potassium Carbonate → HCID 68546653, compound

Participants

Reaction Conditions

Reaction Steps

3-(3-Fluoro-4-iodo-phenyl)-5(R)-[1,2,3]triazol-1-ylmethyl-oxazolidin-2-one (90 mg, 0.232 mmol), 2-Nitro-6(S)-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-ylmethoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (108 mg, 0.278 mmol), K2CO3 (244 mg, 0.464 mmol) and Pd(PPh3)4 (27 mg, 0.023 mmol) were combined and suspended in DMF (2 ml) and water (0.2 ml). The mixture was heated to 60° C. for 1½ hours then quenched with sat. aqueous NH4Cl (2 mL) at rt. The mixture was diluted with EtOAc (10 mL) and washed with water (5 mL×5). The organic phases were dried (MgSO4) and concentrated. Column chromatography (2% MeOH/CH2Cl2) provided 60 mg (50%) of the title product as yellow solid. LCMS (ESI) m/z 523 (M+H+).

Provenance & Evidence