Tetrabutylammonium Fluoride → HCID 68549849, compound

Participants

Reaction Steps

The titled compound was prepared using the same procedure as described previously (see Example 2-1, Step 3), except that 5-(tert-Butyl-dimethyl-silanyloxymethyl)-3-[3-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-oxazolidin-2-one, and 2-(5-Bromo-pyridin-2-yl)-2-methyl-6-nitro-2,3-dihydro-imidazo[2,1-b]oxazole were used as the starting materials, and TBAF deprotection required. The titled compound was obtained as slightly yellow solid (60 mg). ESI MS m/z 456 (M+H). 1H NMR (DMSO-d6) δ 8.79 (s, 1H), 8.14 (s, 1H), 8.05-8.12 (m, 1H), 7.75 (d, J=8.8 Hz, 1H), 7.63 (dd, J=5.2, 2.8 Hz, 1H), 7.48 (dd, J=8.8, 2.0 Hz, 1H), 5.24 (t, J=5.6 Hz, 1H), 4.85 (d, J=10.8 Hz, 1H), 4.69-4.77 (m, 1H), 4.49 (d, J=10.8 Hz, 1H), 4.12 (t, J=8.8 Hz, 1H), 3.86 (dd, J=8.8, 5.6 Hz, 1H), 3.64-3.72 (m, 1H), 3.50-3.59 (m, 1H), 1.97 (s, 3H).

Provenance & Evidence