Trifluoroacetic acid methylene chloride → HCID 68545922, compound

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Reaction Steps

Phosphoric acid mono-(3-{3-fluoro-4-[6-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxy)-pyridin-3-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl) ester was prepared according to the scheme shown in FIG. 17. Phosphoric acid di-tert-butyl ester 3-{3-fluoro-4-[6-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxy)-pyridin-3-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl ester (13 mg) was dissolved with 1 mL TFA/CH2Cl2 (v/v, ½). The resulting solution was stirred at room temperature for 1 hour before all the solvent was removed. The residue was washed with 3 mL CH2Cl2, 3 mL EtOAc and 3 mL MeOH consequently. The residue was dried in vacuo to give the titled compound (8 mg) as white solid. ESI MS m/z 552 (M+H).

Provenance & Evidence