Hexahydro-1,4-diazepine → 1-(5-Bromopyridin-2-yl)-1,4-diazepane

HRID 1446102Notes

Reaction equation

HRID 1446102 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[N:6][CH:7]=1.[NH:9]1[CH2:15][CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>CC#N>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:9]2[CH2:15][CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 27831685-Bromo-2-fluoropyridine

Product 1

HCID 167847331-(5-Bromopyridin-2-yl)-1,4-diazepaneYield 51%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 5-Bromo-2-fluoro-pyridine (2.0 g, 11.4 mmol), [1,4]Diazepane (2.2 g, 22.8 mmol) in CH3CN (5.0 mL) was stirred at 50° C. for 3 hrs. Filter of the solid and the mother solution was brine, and concentrated in vacuo to give the title product (1.47 g, 51%) as a brown solid. ESI MS m/z 256 (M+H+); 1H NMR (400 MHz, CDCl3) δ 8.12 (d, J=7.0 Hz, 1H), 7.45 (dd, J=22.0, 6 Hz, 1H), 6.38 (d, J=22.0 Hz, 1H), 3.66 (m, 4H), 2.81 (t, J=15.0 Hz, 2H), 1.86 (m, 2H).

Workup

  1. filtrationFilter of the solid
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-fcf238dcec02406b9f092dd2581ba7ec
Source dataset
uspto-grants-2010_02
Patent number
US07666864B2

Reaction notes

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