Boronic Acid → Quinoxalin-6-ylboronic acid hydrochloride

HRID 1446111Notes

Reaction equation

HRID 1446111 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([N+:12]([O-])=O)=C2[Cl:15].NC1C=CC(C(CC)(CC)C#N)=CC=1.[BH:30]([OH:32])[OH:31]>>[ClH:15].[N:8]1[C:9]2[CH:10]=[CH:11][C:2]([B:30]([OH:32])[OH:31])=[CH:3][C:4]=2[N:12]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 138269352-(4-Amino-phenyl)-2-ethyl-butyronitrileHCID 219841286-Bromo-4-chloro-3-nitroquinoline

Product 1

HCID 45073595Quinoxalin-6-ylboronic acid hydrochloride

Procedure

The following compounds (Table 2) are prepared in a similar manner as described in Example 1 by reacting 6-bromo-4-chloro-3-nitro-quinoline (Example 1c) with 2-(4-amino-phenyl)-2-ethyl-butyronitrile (Example 12a), and with the appropriate boronic acid:

Workup

  1. customThe following compounds (Table 2) are prepared in a similar manner

Sources & evidence

ORD record
ord-4bcba08be1ea4c92b46c0eb2771eb530
Source dataset
uspto-grants-2010_02
Patent number
US07667039B2

Reaction notes

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