HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 5-(4-Bromophenyl)-4-(pyrrolidin-1-ylcarbonyl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 5-(4-Bromophenyl)-1,2-oxazole-4-carboxylic acid | HCID 22831701 | — |
| Product | 5-(4-Bromophenyl)-4-(pyrrolidin-1-ylcarbonyl)isoxazole | HCID 24809895 | — |
Reaction Steps
The title compound was prepared from 5-(4-bromophenyl)isoxazole-4-carboxylic acid (13.4 mg, 0.050 mmol) and pyrrolidine (4.3 mg, 0.060 mmol) as described in synthetic method A and thereafter purified, first by preparative HPLC method A and then by method B, to give a solid (16.2 mg). MS (pos) m/z 321.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666888B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-5c104a78c01644dd84e6ede0261bcf48 |
| Source note | uspto-grants-2010_02 |