4-Hydroxypyrrolidine → HCID 24809956, compound

HRID 1446178Notes

Reaction equation

HRID 1446178 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[NH:16]1[CH2:20][CH2:19][CH:18]([OH:21])[CH2:17]1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([N:16]2[CH2:20][CH2:19][CH:18]([OH:21])[CH2:17]2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 982104-HydroxypyrrolidineHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 24809956HCID 24809956, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-pyrrolidinol (5.2 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (4.9 mg). HRMS calcd for C15H16N2O3: 272.1161, found 272.1157.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-c8ab971f4c434916994a7c9582a8d4c9
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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