N-methylpiperidine-4-carboxamide → HCID 24809957, compound

HRID 1446179Notes

Reaction equation

HRID 1446179 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[CH3:16][NH:17][C:18]([CH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)=[O:19]>>[CH3:16][NH:17][C:18]([CH:20]1[CH2:25][CH2:24][N:23]([C:13]([C:9]2[CH:10]=[N:11][O:12][C:8]=2[C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=2)=[O:15])[CH2:22][CH2:21]1)=[O:19]

Participants

3

Reactant 2

HCID 2760460N-methylpiperidine-4-carboxamideHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 24809957HCID 24809957, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and piperidine-4-carboxylic acid methylamide (8.5 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (5.1 mg). HRMS calcd for C18H21N3O3: 327.1583, found 327.1580.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-bc8c9c6f550941f0bfdc57876eb2237a
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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