2,6-Dimethylmorpholine, cis- → HCID 24809987, compound

HRID 1446188Notes

Reaction equation

HRID 1446188 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[CH3:16][C@H:17]1[O:22][C@@H:21]([CH3:23])[CH2:20][NH:19][CH2:18]1>>[CH3:23][C@H:21]1[O:22][C@@H:17]([CH3:16])[CH2:18][N:19]([C:13]([C:9]2[CH:10]=[N:11][O:12][C:8]=2[C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=2)=[O:15])[CH2:20]1

Participants

3

Reactant 2

HCID 6415002,6-Dimethylmorpholine, cis-HCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 24809987HCID 24809987, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and cis-2,6-dimethylmorpholine (6.9 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (9.9 mg). Calcd for C17H20N2O3: 300.1474, found 300.1472.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-b428e958365644a69d500bbc43fa3950
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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