1003561-85-0 → HCID 24809989, compound

HRID 1446190Notes

Reaction equation

HRID 1446190 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.Cl.[N:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH:23]2[S:28][CH2:27][CH2:26][NH:25][CH2:24]2)[CH:18]=1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([N:25]2[CH2:26][CH2:27][S:28][CH:23]([C:19]3[CH:18]=[N:17][CH:22]=[CH:21][CH:20]=3)[CH2:24]2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 177498141003561-85-0HCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 24809989HCID 24809989, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 2-pyridin-3-yl thiomorpholine hydrochloride (13 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (11.5 mg). Calcd for C20H19N3O2S: 365.1198, found 365.1200.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-21010a1f047b418682863ec80d70f964
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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