Piperazin-2-one → HCID 24809507, compound

HRID 1446202Notes

Reaction equation

HRID 1446202 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[NH:16]1[CH2:21][CH2:20][NH:19][CH2:18][C:17]1=[O:22]>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([N:19]2[CH2:20][CH2:21][NH:16][C:17](=[O:22])[CH2:18]2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 231360Piperazin-2-oneHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 24809507HCID 24809507, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and piperazinone (6.0 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (4.6 mg). Calcd for C15H15N3O3: 285.1113, found 285.1113.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-f4fc6c84309f4e8a8b70d3005d10444f
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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