HCID 17749749, compound → HCID 59170058, compound

HRID 1446206Notes

Reaction equation

HRID 1446206 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.C(O)(=O)C(O)=O.[F:22][C:23]1[CH:28]=[CH:27][C:26]([CH:29]2[CH2:33][CH2:32][NH:31][CH2:30]2)=[CH:25][CH:24]=1>>[F:22][C:23]1[CH:24]=[CH:25][C:26]([CH:29]2[CH2:33][CH2:32][N:31]([C:13]([C:9]3[CH:10]=[N:11][O:12][C:8]=3[C:5]3[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=3)=[O:15])[CH2:30]2)=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 17749749HCID 17749749, compoundHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 59170058HCID 59170058, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-(4-fluorophenyl)pyrrolidine oxalate (15.3 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (3.3 mg). Calcd for C21H19FN2O2: 350.1431, found 350.1438.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-767119c5ed074549bf1b6c456e6f30f7
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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