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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1446207Generated: October 25, 2026

3-(4-METHYLPHENYL)PYRROLIDINE OXALATE → 5-(4-Methylphenyl)-4-{[3-(4-methylphenyl)pyrrolidin-1-yl]carbonyl}isoxazole

https://huagongshe.com/reaction/1446207

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(4-METHYLPHENYL)PYRROLIDINE OXALATEHCID 17749750—
Reactant5-(p-Tolyl)isoxazole-4-carboxylic acidHCID 22831706—
Product5-(4-Methylphenyl)-4-{[3-(4-methylphenyl)pyrrolidin-1-yl]carbonyl}isoxazoleHCID 59170267—

Reaction Steps

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-(4-methylphenyl)pyrrolidine oxalate (15.1 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (2.7 mg). Calcd for C22H22N2O2: 346.1681, found 346.1692.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07666888B2
Source datasetuspto-grants-2010_02
ORD IDord-b5d6aced2b76448096e28e43cbb73afd
Source noteuspto-grants-2010_02