HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-METHYLPHENYL)PYRROLIDINE OXALATE → 5-(4-Methylphenyl)-4-{[3-(4-methylphenyl)pyrrolidin-1-yl]carbonyl}isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-METHYLPHENYL)PYRROLIDINE OXALATE | HCID 17749750 | — |
| Reactant | 5-(p-Tolyl)isoxazole-4-carboxylic acid | HCID 22831706 | — |
| Product | 5-(4-Methylphenyl)-4-{[3-(4-methylphenyl)pyrrolidin-1-yl]carbonyl}isoxazole | HCID 59170267 | — |
Reaction Steps
The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-(4-methylphenyl)pyrrolidine oxalate (15.1 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (2.7 mg). Calcd for C22H22N2O2: 346.1681, found 346.1692.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666888B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-b5d6aced2b76448096e28e43cbb73afd |
| Source note | uspto-grants-2010_02 |