5-(p-Tolyl)isoxazole-4-carboxylic acid → 5-(4-Methylphenyl)-4-({3-[4-(trifluoromethyl)phenyl]pyrrolidin-1-yl}carbonyl)isoxazole

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Reaction Steps

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-[4-(trifluoromethyl)phenyl]pyrrolidine oxalate (15.1 mg, 0.050 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (5.3 mg). Calcd for C22H19F3N2O2: 400.1399, found 400.1403.

Provenance & Evidence