HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Benzylpyrrolidine → 4-[(2-Benzylpyrrolidin-1-yl)carbonyl]-5-(4-methylphenyl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Benzylpyrrolidine | HCID 339556 | — |
| Reactant | 5-(p-Tolyl)isoxazole-4-carboxylic acid | HCID 22831706 | — |
| Product | 4-[(2-Benzylpyrrolidin-1-yl)carbonyl]-5-(4-methylphenyl)isoxazole | HCID 59170020 | — |
Reaction Steps
The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 2-benzylpyrrolidine (9.7 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (6.8 mg). Calcd for C22H22N2O2: 346.1681, found 346.1694.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666888B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-c9c5bd46b96840e0aa80a0b662208353 |
| Source note | uspto-grants-2010_02 |