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3-Benzylpyrrolidine → 4-[(3-Benzylpyrrolidin-1-yl)carbonyl]-5-(4-methylphenyl)isoxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Benzylpyrrolidine | HCID 3829791 | — |
| 反応物 | 5-(p-Tolyl)isoxazole-4-carboxylic acid | HCID 22831706 | — |
| 生成物 | 4-[(3-Benzylpyrrolidin-1-yl)carbonyl]-5-(4-methylphenyl)isoxazole | HCID 59170080 | — |
反応手順
The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-benzylpyrrolidine (9.7 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (5.8 mg). Calcd for C22H22N2O2: 346.1681, found 346.1693.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07666888B2 |
| 出典データセット | uspto-grants-2010_02 |
| ORD ID | ord-25e0475a69694d138a2d35ef736d5f7d |
| 出典メモ | uspto-grants-2010_02 |