Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1446212Generated: October 30, 2026

3-(4-Methoxybenzyl)pyrrolidine oxalate → 4-{[3-(4-Methoxybenzyl)pyrrolidin-1-yl]carbonyl}-5-(4-methylphenyl)isoxazole

https://huagongshe.com/reaction/1446212

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(4-Methoxybenzyl)pyrrolidine oxalateHCID 17998817—
Reactant5-(p-Tolyl)isoxazole-4-carboxylic acidHCID 22831706—
Product4-{[3-(4-Methoxybenzyl)pyrrolidin-1-yl]carbonyl}-5-(4-methylphenyl)isoxazoleHCID 59170072—

Reaction Steps

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-(4-methoxybenzyl)pyrrolidine oxalate (16.9 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (5.5 mg). Calcd for C23H24N2O3: 376.1787, found 376.1801.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07666888B2
Source datasetuspto-grants-2010_02
ORD IDord-cf81636792724c8ebbc46123958209b6
Source noteuspto-grants-2010_02