HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-[(4-Methylphenyl)methyl]pyrrolidine--hydrogen chloride (1/1) → 4-{[3-(4-Methylbenzyl)pyrrolidin-1-yl]carbonyl}-5-(4-methylphenyl)isoxazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-[(4-Methylphenyl)methyl]pyrrolidine--hydrogen chloride (1/1) | HCID 17749755 | — |
| Edukt | 5-(p-Tolyl)isoxazole-4-carboxylic acid | HCID 22831706 | — |
| Produkt | 4-{[3-(4-Methylbenzyl)pyrrolidin-1-yl]carbonyl}-5-(4-methylphenyl)isoxazole | HCID 59170254 | — |
Reaktionsschritte
The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-(4-methylbenzyl)pyrrolidine hydrochloride (12.7 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (5.8 mg). Calcd for C23H24N2O2: 360.1838, found 360.1848.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07666888B2 |
| Quelldatensatz | uspto-grants-2010_02 |
| ORD ID | ord-e8a0c8e302e24b4ca2d2f22db1d16392 |
| Quellennotiz | uspto-grants-2010_02 |