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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1446215Erstellt: 25. Oktober 2026

3-[(4-Methylphenyl)methyl]pyrrolidine--hydrogen chloride (1/1) → 4-{[3-(4-Methylbenzyl)pyrrolidin-1-yl]carbonyl}-5-(4-methylphenyl)isoxazole

https://huagongshe.com/reaction/1446215

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt3-[(4-Methylphenyl)methyl]pyrrolidine--hydrogen chloride (1/1)HCID 17749755—
Edukt5-(p-Tolyl)isoxazole-4-carboxylic acidHCID 22831706—
Produkt4-{[3-(4-Methylbenzyl)pyrrolidin-1-yl]carbonyl}-5-(4-methylphenyl)isoxazoleHCID 59170254—

Reaktionsschritte

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-(4-methylbenzyl)pyrrolidine hydrochloride (12.7 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (5.8 mg). Calcd for C23H24N2O2: 360.1838, found 360.1848.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS07666888B2
Quelldatensatzuspto-grants-2010_02
ORD IDord-e8a0c8e302e24b4ca2d2f22db1d16392
Quellennotizuspto-grants-2010_02