HCID 17998818, compound → HCID 59170183, compound

HRID 1446216Notes

Reaction equation

HRID 1446216 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.C(O)(=O)C(O)=O.[F:22][C:23]([F:37])([F:36])[C:24]1[CH:35]=[CH:34][C:27]([CH2:28][CH:29]2[CH2:33][CH2:32][NH:31][CH2:30]2)=[CH:26][CH:25]=1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([N:31]2[CH2:32][CH2:33][CH:29]([CH2:28][C:27]3[CH:34]=[CH:35][C:24]([C:23]([F:22])([F:36])[F:37])=[CH:25][CH:26]=3)[CH2:30]2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 17998818HCID 17998818, compoundHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 59170183HCID 59170183, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-[4-(trifluoromethyl)benzyl]pyrrolidine oxalate (19.2 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (4.5 mg). Calcd for C23H21F3N2O2: 414.1555, found 414.1562.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-d2401e2e2c904214988bb0b65352969b
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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