HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Chlorobenzyl)pyrrolidine oxalate → 4-{[3-(2-Chlorobenzyl)pyrrolidin-1-yl]carbonyl}-5-(4-methylphenyl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Chlorobenzyl)pyrrolidine oxalate | HCID 2735373 | — |
| Reactant | 5-(p-Tolyl)isoxazole-4-carboxylic acid | HCID 22831706 | — |
| Product | 4-{[3-(2-Chlorobenzyl)pyrrolidin-1-yl]carbonyl}-5-(4-methylphenyl)isoxazole | HCID 59170091 | — |
Reaction Steps
The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-(2-chlorobenzyl)pyrrolidine oxalate (17.1 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (6.4 mg). Calcd for C22H21ClN2O2: 380.1292, found 380.1300.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666888B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-848f421e6c8c42fb8f8b7e1ede75cf2f |
| Source note | uspto-grants-2010_02 |