HCID 17749758, compound → HCID 59170220, compound

HRID 1446218Notes

Reaction equation

HRID 1446218 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.Cl.Cl.Cl.[NH:19]1[CH2:23][CH2:22][CH:21]([C:24]2[CH:29]=[N:28][CH:27]=[CH:26][N:25]=2)[CH2:20]1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([N:19]2[CH2:23][CH2:22][CH:21]([C:24]3[CH:29]=[N:28][CH:27]=[CH:26][N:25]=3)[CH2:20]2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 17749758HCID 17749758, compoundHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 59170220HCID 59170220, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 2-pyrrolidin-3-yl-pyrazine trihydrochloride (15.5 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (6.0 mg). Calcd for C19H18N4O2: 334.1430, found 334.1426.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-62d7ac83b28c46bf8bf4527bf860a96d
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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