HCID 17749891, compound → HCID 59170202, compound

HRID 1446220Notes

Reaction equation

HRID 1446220 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.Cl.[CH3:17][C:18]1[CH:23]=[CH:22][C:21]([S:24]([CH:27]2[CH2:31][CH2:30][NH:29][CH2:28]2)(=[O:26])=[O:25])=[CH:20][CH:19]=1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([N:29]2[CH2:30][CH2:31][CH:27]([S:24]([C:21]3[CH:22]=[CH:23][C:18]([CH3:17])=[CH:19][CH:20]=3)(=[O:26])=[O:25])[CH2:28]2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 17749891HCID 17749891, compoundHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 59170202HCID 59170202, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-(4-methylphenylsulfonyl)pyrrolidine hydrochloride (15.7 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (12.1 mg). Calcd for C22H22N2O4S: 410.1300, found 410.1303.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-ac1870beb4f44f19b71ee54699efa369
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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